Shares in Spanish pharmaceutical company PharmaMar spiked over 20% on Tuesday after it cited a paper published by peer-reviewed journal Science that confirmed “potent preclinical efficacy” of its drug Aplidin against COVID-19. A study carried out in vitro and in vivo by a team of scientists in New York, San Francisco and Paris showed Aplidin (plitidepsin) leads to a reduction of viral replication, resulting in a 99% reduction of viral loads in the lungs of animals, the Science paper reported, according to a PharmaMar statement.