BARCELONA, Spain, July 6, 2021 — A team of scientists in Spain has directly photomodulated brain-state transitions in vivo using a photoswitchable molecule that was developed previously by researchers at the Institute for Bioengineering of Catalonia (IBEC). By applying a light-responsive molecule called phthalimide-azo-iper (PAI) to the intact brain and subsequently to white light, the researchers were able to modulate slow oscillations in neuronal circuits and reversibly manipulate the oscillatory frequency of the brain.
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